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Simvastatin and niacin et Hypotension

Le résultat de la vérification de l'interaction du médicament Simvastatin and niacin et de la maladie Hypotension pour la sécurité lorsqu'il est utilisé conjointement.

Résultat de la vérification:
Simvastatin and niacin <> Hypotension
Pertinence: 23.07.2019 Réviseur: MD P.M. Shkutko, in

Lors de la vérification de l'interaction selon des sources dignes de confiance Drugs.com, Rxlist.com, Webmd.com, Medscape.com les contre-indications ou des effets secondaires ont été découverts qui peuvent nuire ou renforcer un effet négatif lors des interactions médicament - maladie.

Consommateur:

L'utilisation de la niacine et niacinamide (nicotinamide) est contre-indiqué dans les patients avec des cas d'hypotension grave. Ces agents vasodilatateurs périphériques effets et peuvent souvent causer des bouffées de chaleur, à des doses nettement supérieures à celles pour les exigences physiologiques (par exemple, diminution des lipides sanguins doses).

Sources
  • Knapp TR, Middleton RK "Adverse effects of sustained-release niacin." DICP 25 (1991): 253-4
  • Florkowski CM, Cramb R "Approaches to the management of hypercholesterolaemia." J Clin Pharm Ther 17 (1992): 81-9
  • Simpson T "Extended-release niacin not problem free." Am J Hosp Pharm 48 (1991): 237-8
  • Whelan AM, Price SO, Fowler SF, Hainer BL "The effect of aspirin on niacin-induced cutaneous reactions." J Fam Pract 34 (1992): 165-8
  • Capurso A "Drugs affecting triglycerides." Cardiology 78 (1991): 218-25
  • Knopp RH "New approaches to cholesterol lowering: efficacy and safety." Hosp Pract (Off Ed) 23 Suppl 1 (1988): 22-30
  • DiPalma JR, Thayer WS "Use of niacin as a drug." Annu Rev Nutr 11 (1991): 169-87
  • "Product Information. Slo-Niacin (niacin)." Upsher-Smith Laboratories Inc, Minneapolis, MN.
  • Hoffer A "Niacin reaction." J Fam Pract 34 (1992): 677,680-1
  • Illingworth DR, Stein EA, Mitchel YB, Dujovne CA, Frost PH, Knopp RH, Tun P, Zupkis RV, Greguski RA "Comparative effects of lovastatin and niacin in primary hypercholesterolemia. A prospective trial." Arch Intern Med 154 (1994): 1586-95
  • Hunninghake DB "The pharmacology and therapeutics of lipid-lowering drugs." Am Pharm ns27 (1987): s18-25
  • "Product Information. Nicobid (niacin)." Rhone-Poulenc Rorer, Collegeville, PA.
  • Hoeg JM, Maher MB, Bailey KR, Brewer HB Jr "Comparison of six pharmacologic regimens for hypercholesterolemia." Am J Cardiol 59 (1987): 812-5
  • Davignon J, Roederer G, Montigny M, Hayden MR, Tan MH, Connelly PW, Hegele R, McPherson R, Lupien PJ, Gagne C, et al "Comparative efficacy and safety of pravastatin, nicotinic acid and the two combined in patients with hypercholesterolemia." Am J Cardiol 73 (1994): 339-45
  • Tornvall P, Walldius G "A comparison between nicotinic acid and acipimox in hypertriglyceridaemia--effects on serum lipids, lipoproteins, glucose tolerance and tolerability." J Intern Med 230 (1991): 415-21
  • Ranchoff RE, Tomecki KJ "Niacin or niacinamide? Nicotinic acid or nicotinamide? What is the difference?." J Am Acad Dermatol 15 (1986): 116-7
  • Weiner M "Safety and side effects of sustained-release niacin." JAMA 272 (1994): d514;isc. 514-5
  • Keenan JM, Fontaine PL, Wenz JB, Myers S, Huang ZQ, Ripsin CM "Niacin revisited. A randomized, controlled trial of wax-matrix sustained-release niacin in hypercholesterolemia." Arch Intern Med 151 (1991): 1424-32
  • Truswell AS "ABC of nutrition. Vitamins I." Br Med J (Clin Res Ed) 291 (1985): 1033-5
  • McKenney JM, Proctor JD, Harris S, Chinchili VM "A comparison of the efficacy and toxic effects of sustained- vs immediate-release niacin in hypercholesterolemic patients." JAMA 271 (1994): 672-7
  • Witztum JL "Current approaches to drug therapy for the hypercholesterolemic patient." Circulation 80 (1989): 1101-14
  • Blum CB, Levy RI "Rational drug therapy of the hyperlipoproteinemias, Part II." Ration Drug Ther 20 (1986): 1-4
  • Malloy MJ, Frost PH, Kane JP "Niacin--the long and the short of it." West J Med 155 (1991): 424-6
  • Malinow MR "Adverse effects of the treatment for hyperlipidemia." Cardiol Clin 4 (1986): 95-103
  • Perry RS "Contemporary recommendations for evaluating and treating hyperlipidemia." Clin Pharm 5 (1986): 113-27
Simvastatin and niacin

Nom générique: niacin / simvastatin

Nom de marque: Simcor

Synonymes: Niacin and Simvastatin

Interaction avec les aliments et le mode de vie
Interactions médicamenteuses